(4) Have you ever analyzed why remaining the 10% of patients have not continued with same improvement?

Yes I have. There are many reasons for this. There are patients simultaneously suffering from other diseases. For example, one patient slowly lost improvement after a course of chemotherapy as he was suffering from throat cancer. Some patients do not follow advice and precautions given to them while some have habits like chewing tobacco, smoking etc. which are known to be detrimental for these eye diseases.